I used 24.5gr of Reloader 7. My guide lists 24.8 as the never exceed amount. Bullets shot fine, no keyholing.
I switched to 15.8gr of IMR4227 (never exceed 18gr) because with bullets that heavy, some of them tended to be very long depending on the brand. When I sat the longer bullets into a case with a higher load (i.e. a fuller case) I literally felt and heard the powder being crushed in which I feared may increase pressure to unsafe levels. The IMR load worked just as well and didn't fill up anywhere near the same volume as the Reloader 7 did so I was able to use the longer bullets with no problem.